A Canadian community advancing

Cardiovascular
Critical Care

CANCARE connects clinicians, researchers and trainees to improve care for critically ill cardiovascular patients through collaboration, shared learning and research.

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Latest evidence

Current Research in
Cardiac Critical Care

Concise summaries, clinical context and links to the original research.

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American journal of critical care : an official publication, American Association of Critical-Care Nurses

Efficacy and Safety of Low-Dose Versus Standard-Dose Alteplase to Treat High-Risk Pulmonary Embolism.

Clinical takeaway This small observational cohort found no statistically significant difference in haemodynamic stability or mortality between dosing groups. The shorter ventilation duration is hypothesis-generating rather than evidence of a causal benefit.

Circulation. Cardiovascular interventions

Hemodynamic Effects of Reducing LV Afterload With Impella or Intra-Aortic Balloon Counterpulsation During Veno-Arterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock: HERACLES Trial.

Clinical takeaway This small randomized study suggests a mechanistic advantage for IABP in myocardial oxygen supply-demand balance during VA-ECMO. It does not establish superiority in survival or other patient-centred outcomes.

An annual editorial selection

Top 5 Trials of the Year

A future collection of important trials in cardiovascular critical care.

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